Drug Development and Innovation Centre

The DDIC aims to bridge the gap between basic sciences and clinical research, working through API with industry and academia to design and create the next generation of therapeutic drug delivery.

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With a team of highly specialized researchers and trainees available to assist in the commercialization of modern therapeutic products, the DDIC fosters research and education in pharmaceutical sciences working on translational research and development in the areas of

  • Biopharmaceutics

  • Drug Delivery

  • Quality Control

  • Regulatory Sciences

 

Leadership

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dr. raimar löbenberg, Founder & Director

Dr. Raimar Löbenberg is an expert in area of pharmaceutics, drug development and delivery. He is a member of the United States Pharmacopoeia (USP) expert committee for Dietary Supplements and Herbal Medicines and chair of the subcommittee for performance testing of dietary supplements, member of the American Association of Pharmaceutical Scientists (AAPS) Steering Committee for Drug Release and Dissolution Testing and vice chair of Speciality Committee for Pharmaceutical Quality of Traditional Medicines of the World Foundation of Traditional Chinese Medicines, and a past president of the Canadian Society for Pharmaceutical Sciences. Contact Dr. Löbenberg.

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Dr. Vijay Somayaji, Manager

Dr. Vijay Somayaji has over 30 years of combined academic and biotech industry experience in various areas, including research and development, product development, and quality assurance and quality control. She obtained her Ph.D. in Chemistry from Indian Institute of Science and did her post-doctoral work with Dr. H.C. Brown (Nobel Laureate) at Purdue University (USA). In her various roles, she has managed diverse teams of scientists involved in the characterization of drug substances and drug products, analytical method development (chemical and biochemical), stability testing, clinical sample analyses, and support for regulatory documentation. She has over 50 publications and has been an inventor of two patents. She has also been involved in successful clinical trial applications for more than four drug candidates. Contact Dr. Somayaji.

 

What we do

The DDIC provides specialized prototypes of novel and conventional dosage forms through testing and production of clinical trial materials in its pharmaceutical test laboratory and Health Canada licensed cleanroom. The Centre’s unique infrastructure allows clinical testing support to take place from study design to finished product with access to a rich and diverse pool of experts. 

DDIC offers novel solutions and opportunities in numerous areas for the following groups:

  • Researchers: Novel delivery systems, Nano Formulations, Design and Proof of Concept Studies

  • Pharmaceutical Industry: Product Research and Design, Quality Control, Regulatory Affairs, Analytical Testing, Drug Release Testing, Performance Testing, Production (Liquid, Gel, Semi Solid, Solid), Product Life Cycle Management 

  • Clinical Investigators: Joint Clinical Research, Clinical Trial Dosage Forms (Design and Development)

  • Students and Trainees: Industrial Pharmacy, Regulatory Sciences

 

Facilities & Equipment

The DDIC’s state-of-the-art equipment is capable of processing small to medium quantities of active pharmaceutical ingredients. It provides researchers with the ability to engage in development and performance analysis of a variety of special and conventional dosage forms ranging from tablets and capsules to microemulsions, ointments, creams and nanoparticles. 

The centre adheres to the standards for Good Manufacturing Practices outlined by Health Canada and offers stability testing, according to the protocols of the International Conference on Harmonization (ICH) and received a Health Canada Site License for manufacturing, processing, and packaging in 2009 and has had the license renewed annually.

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Facilities

GMP Compliant Classified Cleanrooms Facility: ISO 6 (Class 1000) and ISO 7 (Class 10,000): for production and packaging, includes a clean room gowning area, clean room formulation facility, clean room filling area

Sterile Products Development Laboratory: for formulation of drug products

GLP Compliant Quality Control Laboratory: for testing of drug products

Prototype Laboratory: for executing project designs

 
 

Product Development Equipment

  • Analytical Balances

  • Blister packaging

  • Capsule filling equipment (000, 00, 0, 1)

  • Comill

  • Containment chamber

  • Customized labelling

  • Double Cone Blender

  • Emulsification equipment

  • Fluid Bed Dryer

  • Fluid Bed Granulator

  • Freeze Dryer

  • Granulators

  • Grinders for controlled size reduction

  • Mixers and Blenders

  • Ointment maker and dispenser

  • Ointment Mill

  • Rotary Tablet Press with instrumentation

  • Screw Capping Machine

  • Single Cone Blender

  • Spray Dryer

  • Suppository Maker

  • Tablet Counting Machine

  • Tablet Press and De-Duster

  • Tube Filler

  • Water Purification System

  • 3D-Chromotographer

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Quality and Performance Characterization Equipment

  • Capsule Filler

  • Disintegration Testing Apparatus (Top Right)

  • Dissolution Testing Apparatuses (1, 2) (Top Left)

  • Flow through Cell (for performance testing of special dosage forms)

  • Franz Cell (for performance testing of special dosage forms)

  • Friability Tester

  • HPLC System; HPLC Systems for chemical analysis (Bottom)

  • Soxhlet Extraction Apparatus

  • Stability Chambers

  • Tablet Hardness Tester

  • Thermal Activity Monitor

  • Thermal Conductivity Tester

  • Weight Checker